Induction of an active oncogene yki, the homolog of human Yap1, in the ISCs leads to malignant tumorigenesis in the gut and subsequent wasting of host organs, including ovary degeneration, lipid loss, muscle dysfunction, hyperglycemia, as well as mortality (Kwon et al., 2015; Song et al., 2019). Here, YAP1 is linked to Hyperglycemia.