RES treated RA by enhancing the apoptosis of fibroblast-like synoviocytes, inhibiting angiogenesis, etc, the mechanism of its inhibition of synovitis included the regulation of NF-κB, MAPK-p38, JAK/STAT, PI3K/AKT, etc signaling pathways (Yang et al., 2017; Yang et al., 2018; Zhang et al., 2019a). The gene discussed is NFKB1; the disease is rheumatoid arthritis.