SIRT1 and atherosclerosis: In the past decades, the role of SIRT1, a longevity-related molecule, in atherosclerosis development has been widely studied not only in VSMCs but also in ECs (Ota et al., 2007; Potente et al., 2007; Zhang et al., 2008) and macrophages (Stein et al., 2010; Zhang et al., 2010; Stein and Matter, 2011), since aging is the independent risk factor for CAD.