In light of the proven crosstalk between SIRT1 and AMPKα activity (Hou et al., 2008; Canto and Auwerx, 2009; Canto et al., 2009), SIRT1 activation can be a potential medical target to improve arterial stiffness and hypertension due to Klotho repression. This evidence concerns the gene SIRT1 and hypertensive disorder.