Recently, Chen and Wang et al. demonstrated that heat shock protein family A member 5 (HSPA5), also termed GRP78, is a negative regulator of DHA or ARS-induced ferroptosis in KRAS mutant pancreatic cancer cells and glioma cells (Chen Y. et al., 2019; Wang K. et al., 2019). The gene discussed is HSPA5; the disease is familial pancreatic carcinoma.