Furthermore, ARTs regulated the crosstalk between autophagy and inflammasomes, which induced the activation absent in melanoma 2 (AIM2)/caspase-1 inflammasome to trigger autophagy in hepatocellular carcinoma and induced autophagy with suppressing the activation of IFI16/caspase-1 inflammasome and IL-1β production together with reducing the expression of ubiquitin-specific processing protease 33 (USP33) and Ras like B (RalB) in human laryngeal squamous cell carcinoma (Shi et al., 2019; Shi et al., 2020). This evidence concerns the gene USP33 and hepatocellular carcinoma.