TNF and systemic lupus erythematosus: Phillyrin (LCW187), one of the most effective constituents in LQ, has good antibacterial and anti-inflammatory activity, which can regulate MyD88/IκBα/NF-kappa B signaling pathway by controlling the expression of IκBα, IL-1β, IL-6 and TNF-α, which would be a benefit to SLE (Yang et al., 2017).