Moreover, LCW regulates the GO molecular function of SLE including protein serine/threonine kinase activity (GO: 0004674, LRRK2, MAPK1, MTOR, EGFR, PRKCB, etc.), transcription factor activity (GO:0098531, PPARG, RXRA, ESR1, STAT3, VDR, etc.), and protein tyrosine kinase activity (GO:0004713, BLK, LYN, JAK1, EPHB2, HSP90AA1, etc.). Here, ESR1 is linked to systemic lupus erythematosus.