Eight out of top 30 genes with the highest weight in the gene regulatory network enriched in the common SLE pathways (hsa05322), including TNF (Geng et al., 2014), HLA-DRB1 (Shimane et al., 2013), IFNG (Leng et al., 2016), CD40LG (Wu et al., 2016), IL10 (Liu P. et al., 2013), FCGR3A (Kyogoku et al., 2013), FCGR2A (Bentham et al., 2015) and TRIM21 (Kyriakidis et al., 2014). Here, TRIM21 is linked to systemic lupus erythematosus.