HMOX1 and myocardial infarction: Angiogenesis participates in the circulatory function recovery from MI, and HSYA exerts the pro-angiogenic effects in two main ways: (1) nucleolin-mediated post-transcriptional regulation of vascular endothelial growth factor-A (VEGF-A) and matrix metalloproteinase (MMP) -9 expressions (Zou et al., 2018); and (2) the up-regulation of heme oxygenase-1 (HO-1)/VEGF-A/stromal cell-derived factor-1α cascade (Wei et al., 2017).