A relevant therapeutic approach could thus include facilitating the clearance of aberrantly folded proteins by increasing autophagy through repressing mTORC1; consistent with this notion, rapamycin treatment restores mTOR activity and rescues neurodegenerative disease model phenotypes (Webb et al., 2003; Ravikumar et al., 2004; Sarkar et al., 2009; Dehay et al., 2010; Menzies et al., 2010; Spilman et al., 2010; Bové et al., 2011; Cortes et al., 2012; Ozcelik et al., 2013; Jiang et al., 2014). The gene discussed is MTOR; the disease is neurodegenerative disease.