ABL1 and neurodegenerative disease: Oxidative stress, protein aggregate accumulation, and damaged mitochondria are common hallmarks of neurodegenerative disease and ABL1 sits at the nexus of the associated signaling pathways with roles in the regulation of receptor endocytosis, DNA repair, autophagy, cytoskeleton dynamics, cell survival, growth, and motility (Gonfloni et al., 2012).