The results revealed that the expression of Bax, cleaved caspase-9/caspase-9, and cleaved caspase-3/caspase-3 could be reduced with L-ASNase pretreatment in the cell model of PD (Figure 3G, *P < 0.05; Figure 3J, *P < 0.05; Figure 3K, ***P < 0.001), while the expression of Bcl2 was increased (Figure 3H, *P < 0.05). Here, CASP3 is linked to Parkinson disease.