Ohrui et al. (2004b) designed a randomized study to investigate the use of ACEIs as a possible treatment for mild-to-moderate AD, in addition to cholinesterase inhibitor. In this study, mini-mental state examination score decline was significantly reduced in AD patients treated with central-acting ACEI compared to other drug classes (Ohrui et al., 2004b). Consistent with these results, the prescription of ACEIs was found to be independently associated with the stability of cognitive function after 1-year follow-up of mild cognitive impairment patients (Rozzini et al., 2006). Here, BCHE is linked to Alzheimer disease.