SOD1 and brain injury: Furthermore, overexpression of SOD was shown to be related to decreased susceptibility to β-amyloid-induced neurotoxicity and ischemic brain injury (Celsi et al., 2004; Chen et al., 2011), yet it has been shown that the activity of antioxidant molecules glutathione, SOD, and catalase decrease with activation of the RAS (Bechara et al., 2005; Rodriguez-Iturbe et al., 2007; Xiong et al., 2010).