Consistent with this, blockade of AT1R and activation of AT2R reverse the hypertension-induced cerebrovascular dysfunction and improve the barrier function of endothelial cells and diabetes-associated cerebral endothelial dysfunction (Alhusban et al., 2013; Gallego-Delgado et al., 2016; Fouda et al., 2019). This evidence concerns the gene AGTR1 and hypertensive disorder.