Since we found an increased immunoreactivity of Cx43 around Aβ plaques in 9-months-old 5XFAD mice, we further asked whether the major partner of Cx43 at A/O heterotypic GJs, Cx47 (Orthmann-Murphy et al., 2007), would be affected in the course of AD pathology. The gene discussed is GJA1; the disease is Alzheimer disease.