Also, oculodentodigital dysplasia is an autosomal dominant syndrome caused by GJA1 (Cx43) gene mutations characterized by CNS demyelination and progressive spastic paraplegia (Paznekas et al., 2003), highlighting the importance of astrocytic coupling with oligodendrocytes, the myelinating cells of the CNS, for the homeostasis and survival of the latter. This evidence concerns the gene GJA1 and oculodentodigital dysplasia.