Since reactive astrocytes are involved in inflammatory responses, surrounding Aβ plaques in AD (Perez-Nievas and Serrano-Pozo, 2018) we further investigated the expression of the major astrocytic Cxs (Cx43 and Cx30) which compose the GJs or HCs in 5XFAD mice. The gene discussed is GJA1; the disease is Alzheimer disease.