We suggest that in the 5XFAD mouse model of AD, the increase of Cx43 but not Cx47 immunoreactivity could possibly indicate the presence of Cx43 in A/A and not in O/A channels, leading to demyelination, just like in chronic EAE and MS (Markoullis et al., 2012a). This evidence concerns the gene GJC2 and myeloid sarcoma.