Even a partial reduction of ganglioside levels in heterozygous B4galnt1+/– mice produces a similar phenotype, although milder, and results in short-term memory loss, heart and colon lesions as well as symptoms of constipation – all of which are characteristic of PD (Chiavegatto et al., 2000; Wu et al., 2012, 2020). Here, B4GALNT1 is linked to Parkinson disease.