CTLA4 and cancer: We next sought to investigate the role of CTLA4 in cancer progression, and the result suggested that the overexpressed CTLA4 was related to high grade (χ2 = 12.465, p < 0.001), advanced stage (χ2 = 22.510, p < 0.001), patient with tumor state (χ2 = 7.874, p = 0.005) and death (χ2 = 9.965, p = 0.002, Table 1).