Functional annotation of putatively selected genes revealed that these genes were predominantly associated with immune-related functions (Supplementary Table 8), inclusive of genes such as C5AR1 and MYH10 (bacterial infection); ARHGEF1, ERCC2 and TRAF2 (viral infection) and IFNGR2 (both viral and bacterial infection). The gene discussed is ARHGEF1; the disease is bacterial infectious disease.