EIF2AK2 and nutritional deficiency disease: Steinert et al.33 found through in vitro experiments that: in breast cancer cells with normal nutrition, BMP2 can promote the occurrence of apoptosis by transcription of apoptosis-related genes (such as PKR, EIF2α); in breast cancer cells with malnutrition, BMP2 can generate ID-1 through the MAPK signal transduction pathway and inhibit the activation of Caspase-3 to enhance the viability of breast cancer cells.