BMP2 and neoplasm: How from the gene level, around the tumor microenvironment change, and the upstream and downstream of BMP2/BMPR shaft signal regulation factor analytic BMP2 and BMPR1B receptor expression in different tissue pathology of different causes and mechanism, the molecular mechanism of organization to maintain dynamic balance of BMP2, BMP2/BMPR shaft and other non BMPR/BMP2/shaft of signaling pathways, artificial synthesis of BMP2 clinical application needs further study.