These 3 polymorphisms in the HMOX1 gene rs3074372 (GT)n repeats, − 413: rs2071746 (A→T) and an intronic variation rs2071749 (A→G) have been earlier studied in disease conditions like Chronic Obstructive Pulmonary Disease (COPD), Parkinson's disease, HIV-induced CNS neuroinflammation, Cardiovascular disease, with their effect on developing a pathologic condition. The gene discussed is HMOX1; the disease is chronic obstructive pulmonary disease.