HUWE1 and neoplasm: Concomitant melphalan application and HUWE1 knockdown resulted in robust suppression of tumour growth (at day 7 post knockdown induction: 10.00 × 108 ± 1.12 × 108 photons/sec vs 38.09 × 108 ± 12.07 × 108 photons/sec in the melphalan-only control group; Fig. 5a,b).