To identify signals in fat tissue that might induce YAP/TAZ activation during obesity, we analyzed whether palmitic acid or several cytokines, including TNFα, interleukin (IL)-1β, CCL2, and IL-6 are able to induce YAP/TAZ target gene expression in 3T3-L1 adipocytes. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.