Next, given recent scRNA-seq data also reported ACE2 expression in goblet cells from nasal turbinates and ethmoid tissues of healthy donors and patients with chronic rhinosinusitis (CRS)20,21, we performed double immunofluorescent staining of ACE2 with Mucin 5AC (MUC5AC), a reliable goblet cell marker. Here, MUC5AC is linked to chronic rhinosinusitis.