CXCL8 and lung cancer: In addition, CXCR2 and two murine functional homologues of IL-8, KC and MIP-2, were investigated in a KrasLA1-induced murine lung cancer model and found to be highly expressed in premalignant alveolar lesions in addition to increased neutrophilic infiltration and a higher vascularity caused by vascular endothelial cells, respectively30.