KRAS and cancer: Recently, Awaji et al.32 have demonstrated that the KRAS/CXCR2 signalling in PDAC promotes phenotype alterations of cancer-associated fibroblasts (CAFs) to a more secretory function, inducing pro-tumourigenic cytokines, mediated by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor.