It has been observed that PI3K/AKT/mTOR pathway is activated in HCC, indeed, increased mTORC1/2 and downstream targets AKT, S6 and 4EBP-1 were activated in HCC as determined based on Rictor, Raptor over-expressions and enhanced Akt phosphorylation (Ser473). The gene discussed is AKT1; the disease is hepatocellular carcinoma.