UBE3A and autism: Moreover, in a study describing methylation-sensitive high-resolution melting-curve analysis on genomic DNA of post-mortem human brain tissues obtained from 8 Dup15q syndrome, 10 idiopathic autism and 21 typical control individuals34, PWS-IC methylation, and UBE3A transcript and protein levels were higher in Dup15q than in control or autism samples.