SERPINE1 and Hypertension: Furthermore, EVs isolated from macrophages under hypertension were enriched with miR-17 and induce the expression of cytokines, such as intercellular adhesion molecule-1 (ICAM-1) and plasminogen activator inhibitor-1 (PAI-1), in ECs via activating the NF-κB pathway, which ultimately promote cardiac inflammation and pathological cardiovascular remodeling78.