BAX and central nervous system cancer: In conclusion, α-m-Dox/M was synthesized by self-assembly for the delivery of α-m and Dox to tumor cells, thereby inhibiting the growth of glioma cells by blocking cells in S phase via CDKs/cyclins and promoting cell apoptosis via the Bcl-2/Bax pathway in vitro, suppressing glioma development and prolonging mouse survival time with minimal toxicity by reducing angiogenesis, and promoting apoptosis and inhibiting proliferation of tumor cells in vivo.