In conclusion, α-m-Dox/M was synthesized by self-assembly for the delivery of α-m and Dox to tumor cells, thereby inhibiting the growth of glioma cells by blocking cells in S phase via CDKs/cyclins and promoting cell apoptosis via the Bcl-2/Bax pathway in vitro, suppressing glioma development and prolonging mouse survival time with minimal toxicity by reducing angiogenesis, and promoting apoptosis and inhibiting proliferation of tumor cells in vivo. The gene discussed is BCL2; the disease is glioma.