Our study suggested that the blockage of the cell cycle in S phase induced by α-m-Dox/M contributed to the suppression of glioma cell proliferative activity by upregulating the expression of p21 and p53 and downregulating the expression of CDK2, cyclin E1, cyclin D1, p-FoxO1/FoxO1 and p-Akt/Akt. Here, TP53 is linked to glioma.