We started with pancreatic cancer CSCs (PANC-1 CSLC and PSN-1 CSLC) and determined the effect of dexamethasone on the expression of stem cell–associated markers (CD133, Sox2, Nanog, Bmi1, and Nestin) and the differentiation marker E-cadherin. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.