We started with pancreatic cancer CSCs (PANC-1 CSLC and PSN-1 CSLC) and determined the effect of dexamethasone on the expression of stem cell–associated markers (CD133, Sox2, Nanog, Bmi1, and Nestin) and the differentiation marker E-cadherin. The gene discussed is PROM1; the disease is pancreatic neoplasm.