ATXN2 and proteostasis deficiencies: Finally, it would be interesting to see if colocalization of ATXN2 and pathogenic proteins and the decrease in ATXN2 expression are specific to FTLD-TDP or if they occur in other TDP-43 proteinopathies including limbic-predominant age-related TDP-43 encephalopathy and other proteinopathies such as tauopathies and alpha-synucleinopathies to elucidate the pathogenesis of these neurodegenerative disorders.