Notably, a recent report regarding extracellular signal-regulated kinases (ERK) in KRAS-mutated PDAC, based on cell lines, pancreatic cancer organoids, and xenograft mouse-models, showed that ERK inhibition in cancer-associated stromal cells can suppress cancer-stromal interactions and PDAC metastatic potential [24]. Here, KRAS is linked to familial pancreatic carcinoma.