We further compared the gene expression levels in Fig. 7b among different tumor stages, T categories, grades and patients’ states, and found that the levels of integrin subunit alpha 5 (ITGA5), TGFβ2, platelet-derived growth factor subunit B (PDGFB), and G protein subunit gamma 11 (GNG11) were changed with statistical difference in the above four terms (Fig. 7c, Additional file 12: Table S11). Here, ITGA5 is linked to neoplasm.