For evaluating the correlation of these four genes with ferroptosis and iron metabolism, we detected in this study that the encoded proteins of the four genes were strongly positive in the tumor tissues of HCC patients, and further validated in the mouse models that expression of ABCB6, FLVCR1 and SLC7A11 were down-regulated in tumor tissues treated by ferroptosis inducer erastin. Here, SLC7A11 is linked to hepatocellular carcinoma.