The expression levels of ABCB6, FLVCR1, SLC48A1, and SLC7A11 were significantly higher in the HCC cohort from ICGC than in normal samples (P < 0.001) (Fig. 8a-d), which was consistent with the predictive analysis of diagnosis and prognosis, demonstrating that the four genes were suitable for constructing diagnostic and prognostic models. The gene discussed is SLC48A1; the disease is hepatocellular carcinoma.