It is essential to exclude previous respiratory conditions that may influence lung function and control variables that are indicatives of inflammation, including CRP, erythrocyte sedimentation rate, FeNO or serum levels of leptin, adiponectin, IL-6 and TNF-α, which will allow precise determination of the influence of overweight in lung function of children and adolescents with obesity. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.