SPRY4 and glioblastoma: Derepression of CIC target genes (ETV1/4/5, DUSP6, SPRY4) was also observed following siRNA knockdown of ATXN1L in GBM (Fig. 5g, Additional file 7: Figure S6C) and BTIC (Additional file 7: Figure S6D) cell lines, while siRNA knockdown of TRIM25 resulted in further repression.