TRIM25 and hepatocellular carcinoma: Although the majority of TRIM25 studies have been focussed on its role as a negative regulator of viral replication, several studies have also suggested that overexpression of TRIM25 may promote tumor progression in hepatocellular carcinoma [39] and lung cancer [40], cell growth and proliferation in prostate adenocarcinoma [41] and breast cancer [42], and metastasis in breast cancer [33], supporting the role of TRIM25 as an oncogene.