Overexpression of TRIM25 was found to dysregulate similar genes and pathways as CIC loss in both in vitro cell lines and TCGA patient samples suggesting that the CIC-ATXN1L-TRIM25 axis may be an important regulator of cell growth and proliferation in several cancer types including breast carcinoma and liver hepatocellular carcinoma. The gene discussed is ATXN1L; the disease is cancer.