To determine if TRIM25 may regulate the transcription factor functions of CIC, differentially expressed (DE) genes using published gene expression data of TRIM25 knockdown in breast cancer cell lines (BT549 and MDA-MB-231, Additional file 8: Table S2) from Walsh et al. [33] were compared to DE genes identified in CICKO and ATXN1LKO NHA cell lines (Additional file 9: Table S3A, B). The gene discussed is TRIM25; the disease is breast carcinoma.