BDNF and chronic cystitis: Future iterations of the BN described here could also include tolerability and safety measures, including dissociative phenomena, cystitis and urinary incontinence; and other variables such as pre-treatment biochemistry (e.g., brain-derived neurotrophic factor), neurochemistry (e.g., glutamine/glutamate ratio), neuroimaging (e.g., anterior cingulate cortex activity), and cognitive functioning (i.e., processing speed).