As we can see from Fig. 2 a–f, high level of E2F2 was significantly correlated with histologic grade (p = 1.605e− 07), clinical stage (p = 0.022), T (T1/T2 vs. T3/T4, p = 0.011), tumor status (p = 0.006), AFP (p = 1.726e− 07), family history (p = 0.041). This evidence concerns the gene E2F2 and neoplasm.