Therefore, we analyzed the E-cadherin expression in 17 MSI-H CRCs with known CTNNB1 mutational status (10 homo- or hemizygous, 2 heterozygous, 5 wildtype) Strong reduction of E- Cadherin was found in 11 cancers while 6 CRCs displayed an expression similar to that in surrounding epithelium (Fig. 3). This evidence concerns the gene CDH1 and cancer.