IP-10 was the only serum biomarker independently associated with CM mortality vs. SMA and NM. CSF IL-1ra, IL-8, IP-10, PDGF-BB, MIP-1β, Fas-L, sTNF-R1, and sTNF-R2 were significantly elevated in cerebral malaria vs. severe malarial anemia and non-malarial mortality group. Here, CXCL10 is linked to cerebral malaria.