TNF and brain ischemia: Rupture of aneurysm will cause subarachnoid hemorrhage and studies revealed that intrathecal secretion of inflammatory cytokines, including IL-1,IL-6 and TNF-α, was significantly increased in these patients with poor clinical outcome [14,15], they hypothesized that an overwhelming inflammatory response in the subarachnoid space plays a central part in pathogenesis of vasospasms and subsequent cerebral ischemia [15].