Levels of VDAC1 expression may be increased by a variety of agents, for example, in A375 human malignant melanoma cells by the tyrosinase inhibitor arbutin (hydroquinone-O-beta-D-glucopyranoside) [167], but increases in expression were also seen in acute lymphoblastic leukemia (ALL) cell lines following prednisolone treatment [168]. Here, TYR is linked to acute lymphoblastic leukemia.