Importantly, reducing the levels of VDAC1 with a specific siRNA, or our newly developed small molecules, e.g., VBIT-4 and VBIT-12, could inhibit VDAC1 oligomerization, correct the misdirection of the protein to the plasma membrane (PM) [84], and prevent mitochondria dysfunction and apoptosis [53] in both T2D [84] and models of lupus [87]. The gene discussed is VDAC1; the disease is type 2 diabetes mellitus.