VDAC1 and systemic lupus erythematosus: We found that VDAC1 oligomers in the OMM promoted mtDNA release and our small molecule, VBIT-4, which inhibits VDAC1 oligomerization, decreased mtDNA release, type-Ι interferon signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus.