VDAC1-silencing strategy—we recently demonstrated that using specific si-RNA to silence human VDAC1 (si-hVDAC1) in cultured cells and in mouse models reduced cell energy homeostasis and inhibited the growth of various cancer cell types including glioblastoma multiforme (GBM), lung cancer, and triple negative breast cancer [85,86,343]. The gene discussed is VDAC1; the disease is cancer.