Detection of a single prostasome specific protein, even when ubiquitously expressed, in a total EV fraction isolated from blood may be sufficient to detect prostate cancer, as exemplified by a study in which the antiapoptotic protein survivin was found to be significantly increased in EV isolated from the plasma of prostate cancer patients compared to patients with proinflammatory benign prostate hyperplasia or healthy controls [65]. Here, BIRC5 is linked to benign prostatic hyperplasia.