In vitro [6,7,38,39] and in vivo studies [16,40,41,42,43,44] have shown that, in the tumor, CCL18 is produced in large amounts by TAMs, and also in smaller amounts by cancer-associated fibroblasts (CAF) [45] and cancer cells such as colon cancer cells [46], glioblastoma multiforme cells [40], non-small cell lung cancer cells [7], melanoma cells [47], and renal cell carcinoma cells [48]. Here, CCL18 is linked to hereditary clear cell renal cell carcinoma.