ESR2 and cancer: The growth-inhibitory effects of E2-bound ERβ in TNBC cells were reported to be due to inhibition of cyclin dependent kinases 1 and 7 and by regulation of genes involved in Wnt/β-catenin pathway (DKK1, WNT4, and CDH1) and in the G1/S cell cycle checkpoint control (CDKN1A), which are two signaling pathways well known for their role in cancer cell proliferation [41,42].