BECN1 and hepatocellular carcinoma: Specifically in HCC, the autophagy pathway seems to depend on two pathways, beclin-1-dependent and beclin-1-independent, and on the activation of other mediators such as the epidermal growth factor receptor (EGFR)/tyrosine-protein kinase Met (c-Met), NF-κB, MAPK, mTOR, and JNK kinases.