In addition, increased levels of estrogen, progesterone, and adipocyte-derived hormones such as adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukin-6 (IL6), and C-reactive protein (CRP) are also suggested to play a role in the development of insulin resistance during pregnancy [14,20,24,25,26]. This evidence concerns the gene TNF and Insulin resistance.