However, colon levels of PEA are increased in animals with experimental colon inflammation treated with the selective NAAA inhibitor AM9053 [31], and the selective NAAA inhibitor ARN077 restores the reduced PEA levels seen in the sciatic nerve following chronic constriction injury [32] and in paws treated with complete Freund’s adjuvant [33]. The gene discussed is NAAA; the disease is colitis.