Qin et al. reported that tacrine platinum(II) complexes exhibited cytotoxic activity in NCIeH460, Hep- G2, SK-OV-3, SK-OV-3/DDP and MGC80-3 cancer cells and induced cell apoptosis by means of activation of the p53 signalling pathway and dysfunction of mitochondria [87]. The gene discussed is TP53; the disease is cancer.