Asb2 was also demonstrated to ubiquitylate talin-1 (Tln1) [310], a protein that is together with talin-2 required for myoblast fusion and sarcomere assembly of skeletal muscles [311], and whose loss results in costameric instability and dilated cardiomyopathy in hearts [312]. Here, TLN1 is linked to dilated cardiomyopathy.