JUN and neoplasm: It is a well-known tumor suppressor that degrades oncoproteins such as cyclin-E, notch receptor 1 (Notch1), c-Jun (Jun proto-oncogene, AP-1 transcription factor subunit), c-Myc (Myc proto-oncogene), or the mammalian target of rapamycin kinase (mTOR) [137,138,139,140,141].