CASP8 and Huntington disease: Caspase-8, for example, interacts with core components of the NLRP3 inflammasome and is required for caspase-1 activation [20], and caspase-4 is able to induce pyroptosis via gasdermin D cleavage, but, because neither caspase-4 nor caspase-8 transcripts were different in our cohorts, both proteases probably do not contribute to elevated pyroptosis measured in HD patients.