INS and obesity due to melanocortin 4 receptor deficiency: Increased visceral fat mass is viewed as an important independent risk factor for obesity-related metabolic dysfunction and health problems, such as atherogenic dyslipidemias, aberrant glucose–insulin homeostasis, chronic low-grade inflammation, and ectopic fat deposition, as well as being associated with increased morbidity and mortality in general [20,39,40,41,42].