The immediate early genes (IEG) and early growth responses 1–3 (EGR1–3) have been found to be upregulated in blood of a subset of patients with ME/CFS [5], in most of which EBI2 was also found to be upregulated [3], suggesting that these two phenomena are linked in ME/CFS. Here, EGR1 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.