Significantly high promoter methylation at specific genes such as SOX7 [70], GPX3 [74], miR-124 [91], SOCS1 [113], DLX4 [73], DLX5 [114], sFRP1/4/5 [77], p73 [115], VTRNA1-3 [116], CDKN2B [76,113], HIC1, CDH-1, ER [117], and ABAT [69] is associated with low OS rates and/or poor prognosis in MDS patients, and many are independent prognostic factors for MDS. The gene discussed is GPX3; the disease is myelodysplastic syndrome.