It was recently shown that CpG island methylation associated with six genes (ABAT, DAPP1, FADD, LRRFIP1, PLBD1, and SMPD3) in bone marrow cells is a marker of MDS, and could diagnose MDS with 95% specificity and 91% sensitivity [68]. This evidence concerns the gene PLBD1 and myelodysplastic syndrome.