For example, as already mentioned, EGFR activation by EGF binding can induce PD-L1 expression on tumor cells; however, EGFR-mutant NSCLCs tend to have lower PD-L1 expression levels compared to EGFR-wild type tumors as a result of the interaction between tumor cells and the immune TME [38,39,40]. Here, EGF is linked to neoplasm.