CD274 and adenocarcinoma: Concurrent PTEN and STK11 loss favors, in vivo, the growth of squamous NSCLC with high PD-L1 expression [56], while lung tumors with adenocarcinoma histology and high PD-L1 expression can be observed in mice where PTEN is simultaneously lost with Kelch-like ECH-associated protein 1 (KEAP1), rather than STK11 [57].