CD274 and neoplasm: COP9 signalosome 5 (CSN5) is involved in TNF-a-mediated PD-L1 stabilization because of its function in deubiquitination of PD-L1 and its inhibition by curcumin may benefit immunotherapy in the reduction of tumor growth such as demonstrated in in vivo preclinical mouse models treated with CTLA-4 antibodies [155].