KIF2C and cancer: Given that excessive tubulin detyrosination might lead to chromosomal instability by suppressing the error correction activity of MCAK and Kif2b [37], together with the observed upregulation of tubulin detyrosination in invasive cancer and with poor prognosis (Table 1), it raises the exciting possibility that an increase in tubulin detyrosination might promote cancer progression through inhibition of the mitotic error correction machinery.